Holistic approach in the management of PCOS: a pilot study of an online PCOS-reversal program

Background: Polycystic ovary syndrome (PCOS) is a complex disorder that can be managed but not permanently cured. Each woman has her own PCOS symptoms and its own root causes. A number of medications are prescribed to women with PCOS. However, a holistic approach could be the best way forward in managing a disease as complex as PCOS. Authors conducted this pilot study called the Sepalika 5-petal PCOS reversal program which consisted of individualized diet plans, magnet acutherapy, fitness regimens, dietary supplements and herbal products to evaluate whether these interventions improve PCOS symptoms, insulin resistance and hyperandrogenism.Methods: A total of 30 patients were recruited online from all parts of India using the PCOS symptom quiz. Various baseline investigations were performed at recruitment. They were suggested personalized diet plans, followed by exercise videos, magnetic acutherapy and herbal and micronutrient supplements. The program spanned over a period of 90 days and patients outlook and quality of life were also assessed at the end of the program.Results: The main goal of most participants was improvement in weight and energy issues, and regularization of periods. Each of these goals were achieved in all participants of the program. Patient-reported outcomes showed a definite improvement in the quality of life of the participants at the end of 90 days.Conclusions: PCOS is a physical - sexual, psychological and social syndrome; therefore, it is necessary to taking a more holistic approach to patient care beyond treating physical symptoms. Larger studies with more objective and subjective endpoints is the way forward

CONTROLLING IP SPOOFING THROUGH INTER DOMAIN PACKET FILTERS

IP Spoofing is a serious threat to the legitimate use of the Internet. By employing IP spoofing, attackers can overload the destination network thus preventing it from providing service to legitimate user. In this paper, we propose an inter domain packet filter (IDPF) architecture that can minimize the level of IP spoofing on the Internet. A key feature of our scheme is that it does not require global routing information.  IDPFs are constructed from the information implicit in Border Gateway Protocol (BGP) route updates and are deployed in network border routers.  We establish the conditions under which the IDPF framework correctly works in that it does not discard packets with valid source addresses. We show that, even with partial deployment on the Internet, IDPFs can proactively limit the spoofing capability of attackers. In addition, they can help localize the origin of an attack packet to a small number of candidate networks

p-adic L-functions for GSp(4) x GL (2).

Let p be an odd prime. In this thesis we construct a p-adic analog of a degree eight L-function L(s,Fxf) where F is an ordinary holomorphic degree 2 Siegel eigen cusp form of level a power of p and f is an ordinary eigen cusp form of level a power of p. Our method makes use of the work of M. Furusawa which gives an integral representation for this L-function. By suitably interpreting this integral representation in the context of inner products of automorphic forms, we show that it p-adically interpolates the L-values as the forms F and f vary in ordinary families (with the weights varying p-adically). This interpolation is carried out by constructing an Eisenstein measure on a higher-rank unitary group and exploiting a pull-back formula of P. Garrett and G. Shimura.Ph.D.MathematicsUniversity of Michigan, Horace H. Rackham School of Graduate Studieshttp://deepblue.lib.umich.edu/bitstream/2027.42/57644/2/mkagarwa_1.pd

Complexes of Oxozirconium(IV) Perchlorate, Nitrate and Thiocyanate with Some Heterocyclic Bases

A number of oxozirconium(IV) perchlorate, nitrate and thiocyanate adducts with various heterocyclic bases have been synthesized. The compounds were characterized by elemental analysis, molar masses, electrical conductance and infrared spectra. In all perchlorate complexes both perchlorate groups are outside the coordination sphere, in nitrate complexes the nitrate groups are bicovalently bonded, while in thiocyanate complexes the thiocyanate groups are N-bonded. The coordination number of Zr(IV) in these compounds is either five or seven, depending on the anions present. The thermogravimetric analyses of the compounds are also been given

Clinical efficacy of clonidine versus nalbuphine as intrathecal adjuvants to 0.5% hyperbaric bupivacaine for subarachnoid block during gynaecological procedures: a double blind study

Background: Regional anesthesia techniques for gynaecological procedures are on increasing trends due to their advantage of postoperative analgesia owing to intrathecal adjuvants. The present study was aimed to comparatively evaluate the clinical efficacy of clonidine with nalbuphine when co-administered intrathecally with 0.5% hyperbaric bupivacaine for gynaecological procedures.Methods: Regional anesthesia techniques for gynaecological procedures are on increasing trends due to their advantage of postoperative analgesia owing to intrathecal adjuvants. The present study was aimed to comparatively evaluate the clinical efficacy of clonidine with nalbuphine when co-administered intrathecally with 0.5% hyperbaric bupivacaine for gynaecological procedures.Results: The onset of sensory block was earlier in patients of Group BN (3.91±2.25 min vs 4.30±0.87 min, p=0.039). The onset of motor block was also earlier in patients of Group BN (p=0.042). The time to first rescue analgesia in patients receiving intrathecal clonidine was significantly delayed (283±14.18 min vs 231.50±26.18 min, p=0.001). Intraoperative hemodynamic changes were comparable and none of the patient suffered from respiratory depression, shivering, nausea or vomiting.Conclusions: Intrathecal clonidine as adjuvant to bupivacaine provided was clinically more effective than nalbuphine for prolonging the duration of analgesia for gynaecological procedures

Storing entanglement of nuclear spins via Uhrig Dynamical Decoupling

Stroboscopic spin flips have already been shown to prolong the coherence times of quantum systems under noisy environments. Uhrig's dynamical decoupling scheme provides an optimal sequence for a quantum system interacting with a dephasing bath. Several experimental demonstrations have already verified the efficiency of such dynamical decoupling schemes in preserving single qubit coherences. In this work we describe the experimental study of Uhrig's dynamical decoupling in preserving two-qubit entangled states using an ensemble of spin-1/2 nuclear pairs in solution state. We find that the performance of odd-order Uhrig sequences in preserving entanglement is superior to both even-order Uhrig sequences and periodic spin-flip sequences. We also find that there exists an optimal length of the Uhrig sequence at which the decoherence time gets boosted from a few seconds to about 30 seconds.Comment: 6 pages, 7 figure

The comparative study of applanation and optical coherence biometry methods for the intra ocular lens power calculation

Purpose: To compare applanation biometry (A-Scan) and optical coherence biometry (AL-Scan) methods for IOL power calculation based on Axial Length and post operative refractive outcome. Methodology: Prospective and Interventional Randomized Comparative Study, Sample size of 400, studied under two sub groups, for Axial Length readings and IOL power calculation by A-Scan (Biomedix) and AL-Scan (Nidek). Keratometry readings are taken only by AL-Scan.Results: Mean ± St. dev. of A.L. measured by App. Biometry was low (22.79 ± 0.9 mm) than Opt. Coh. Biometry (23.16 ± 0.78 mm) to be significant (P= .0001). Mean ± St. dev. IOL power was higher (21.75 ± 2.1D) than App. Biometry (20.88 ± 1.59 D) to be significant (P= 0.0001). Mean ± St. dev. of refractive status for Myopia is higher -0.97 ± 0.53 by App. Biometry than Opt. Coh. Biometry -0.5 ± 0.19, to be significant (P= 0.0001) and Mean ± St.dev. for Hyperopia is higher 0.98 ± 0.59 by App. Biometry than Opt. Coh. Biometry 0.46 ± 0.18, to be significant (P= 0.0001). Bland–Altman plots showed perfect agreement between both methods regarding A.L. and calculated IOL power. Further subgroup analysis revealed a statistically significant difference in different age groups and types of cataract for Posterior Sub capsular cataract alone and Nuclear Sclerosis with Posterior Sub capsular cataract (P= 0.001). Conclusion: There is significant difference between App. and Opt. Coh. Biometry; however, certain situations of Cataract is demanding mandatory role of App. Biometry

Nonsteroidal Management of Accidental Extrusion of Sodium Hypochlorite beyond Apex

Sodium hypochlorite is often used as an intracanal irrigant in root canal treatment for removal of organic debris. It is also used for its ability to dissolve pulpal tissues, removal of organic debris from smear layer. Despite its safe properties, serious complications can result from inadvertent use. The present case report discusses the inadvertent effects and management of accidental extrusion of concentrated NaOCl and nonsteroidal management. Extrusion of NaOCl beyond the root canal can occur when there is iatrogenic widening of the apical foramen, lateral perforation, or wedging of the irrigating needle. Injudicious use of the irrigant should be avoided to prevent the NaOCl accidents. This report demonstrates destructive effect of concentrated NaOCl solution on soft tissues and subsequent management of the case